Open AccessROLE OF OXIDATIVE STRESS AND CARBOHYDRATE METABOLISM IN THE HEART AND VASCULAR REMODELING IN PATIENTS WITH ARTERIAL HYPERTENSION ASSOCIATED WITH TYPE 2 DIABETES MELLITUS
Author(s) -
M. M. Kochyeva,
Yа.K. Radzishevska,
Ie. B. Radzishevska,
G. V. Linska
Publication year - 2015
Publication title -
problemi endokrinnoï patologìï
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 2
eISSN - 2518-1432
pISSN - 2227-4782
DOI - 10.21856/j-pep.2015.4.04
Subject(s) - diabetes mellitus , oxidative stress , antioxidant , medicine , carbohydrate metabolism , cardiology , type 2 diabetes mellitus , endocrinology , antioxidant capacity , biology , biochemistry
In the previous stages of research four integrated ultrasound parameters of heart and blood vessels state (factors) were proposed using the method of factor analysis. These factors had been defined as a linear combination of traditional ultrasound fourteen indicators. In the proposed paper the canonical correlations of these factors with three sets of laboratory indicators of oxidative stress, antioxidant defense, carbohydrate metabolism and existence of mutually directed multivariate correlations between them had been studied. The violation of carbohydrate metabolism was an integral part of the heart and vascular remodeling in patients with arterial hypertension associated with type 2 diabetes mellitus. To improve the diagnostic of antioxidant defense the definition the total antioxidant activity of red blood cells is advisable. Pathogenetically reasonable use of medicines with antioxidant properties was grounded.