Open AccessPANCREATIC AND EXTRA PANCREATIC EFFECTS OF GLYMEPIRIDE
Author(s) -
Н. А. Кравчун
Publication year - 2021
Publication title -
problemi endokrinnoï patologìï
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 2
eISSN - 2518-1432
pISSN - 2227-4782
DOI - 10.21856/j-pep.2015.3.16
Subject(s) - lipotoxicity , hyperinsulinemia , insulin resistance , diabetes mellitus , medicine , pancreas , type 2 diabetes , insulin , endocrinology
Insulin resistance (IR) and hyperinsulinemia (GI) play a leading role in the development of macrovascular complications in type 2 diabetes mellitus (DM), which are the main cause of mortality in these patients. Taking into account the decisive importance of gluco- and lipotoxicity in the development of microangiopathies, the main goal of antidiabetic pharmacological correction is to influence IR and dysfunction of β-cells of the pancreas