BIOCHEMICAL MARKERS OF VASCULAR DISFUNCTION INDUCED BY TYPE 2 DIABETES IN FEMALE RATS WITH NORMO- OR HYPOESTROGENIC STATE | Zendy

Oleksii Borikov | Zendy; Nataliia Gorbenko | Zendy; Olha Ivanova | Zendy; Tetiana Kiprich | Zendy; К. В. Таран | Zendy; S. D. Trzhetsynskyi | Zendy

Open Access

BIOCHEMICAL MARKERS OF VASCULAR DISFUNCTION INDUCED BY TYPE 2 DIABETES IN FEMALE RATS WITH NORMO- OR HYPOESTROGENIC STATE

Author(s) -

Oleksii Borikov,

Nataliia Gorbenko,

Olha Ivanova,

Tetiana Kiprich,

К. В. Таран,

S. D. Trzhetsynskyi

Publication year - 2015

Publication title -

problems of endocrine pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.141

H-Index - 2

eISSN - 2518-1432

pISSN - 2227-4782

DOI - 10.21856/j-pep.2015.3.12

Subject(s) - endocrinology , medicine , oxidative stress , diabetes mellitus , estrogen , type 2 diabetes , nitric oxide synthase , insulin resistance , nitric oxide , biology

The effect of estrogen deficiency on the biochemical parameters of vascular dysfunction induced by type 2 diabetes in female rats was investigated. It was shown that hypoestrogenic state in combination with diabetes promotes more expressive manifestation of insulin resistance and enhances oxidative stress in the blood serum. However, estrogens level does not influence on the hyperglycemia development and changes in activity of nitric oxide synthase and heme oxygenase in the vessels of diabetic animals.

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