Open AccessBIOCHEMICAL MARKERS OF VASCULAR DISFUNCTION INDUCED BY TYPE 2 DIABETES IN FEMALE RATS WITH NORMO- OR HYPOESTROGENIC STATE
Author(s) -
Oleksii Borikov,
Nataliia Gorbenko,
Ivanova Ov,
Tetiana Kiprich,
К. В. Таран,
S. D. Trzhetsynskyi
Publication year - 2015
Publication title -
problemi endokrinnoï patologìï
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 2
eISSN - 2518-1432
pISSN - 2227-4782
DOI - 10.21856/j-pep.2015.3.12
Subject(s) - endocrinology , medicine , oxidative stress , diabetes mellitus , estrogen , type 2 diabetes , nitric oxide synthase , insulin resistance , nitric oxide , biology
The effect of estrogen deficiency on the biochemical parameters of vascular dysfunction induced by type 2 diabetes in female rats was investigated. It was shown that hypoestrogenic state in combination with diabetes promotes more expressive manifestation of insulin resistance and enhances oxidative stress in the blood serum. However, estrogens level does not influence on the hyperglycemia development and changes in activity of nitric oxide synthase and heme oxygenase in the vessels of diabetic animals.