Open AccessCLASS G AUTOANTIBODIES TO OXIDATIVELY MODIFIED LOW DENSITY LIPOPROTEIN IN TYPE 2 DIABETES MELLITUS PATIENTS WHO HAVE HAD NON-Q-MYOCARDIAL INFARCTION
Author(s) -
Н. В. Алтуніна,
V. G. Lizogub,
O. N. Bondarchuk
Publication year - 2021
Publication title -
problemi endokrinnoï patologìï
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 2
eISSN - 2518-1432
pISSN - 2227-4782
DOI - 10.21856/j-pep.2015.3.01
Subject(s) - autoantibody , medicine , diabetes mellitus , endocrinology , type 2 diabetes mellitus , insulin resistance , low density lipoprotein , lipoprotein , myocardial infarction , type 2 diabetes , concomitant , insulin , cholesterol , immunology , antibody
The article presents the results of a study of class G autoantibodies to oxidatively modified low-density lipoprotein (ox-LDL) in patients with type 2 diabetes mellitus which have had non-Qmyocardial infarction and their connection with disturbances of carbohydrate and lipid metabolism, the levels of cytokines. It was identified the decrease level of IgG to ox-LDL in the serum of these patients compared with the control group and patients without diabetes. The study found that with increasing degree of insulin resistance, the concentration of class G autoantibodies to ox-LDL in diabetic postinfarction patients was reduced. It was also revealed their direct connection with the level of anti-inflammatory IL-10. The data obtained may be evidence of the negative impact of carbohydrate metabolism disorders on the level of IgG autoantibodies to ox-LDL and the data may refer to their protective role in type 2 diabetes mellitus with concomitant atherosclerosis.