Open AccessCORRECTION OF THE IMPAIRED GLUCOSE TOLERANCE IN THE ELDERLY. FOCUS — INHIBITORS OF THE DIPEPTIDYL PEPTIDASE-IV (REVIEW AND OWN DATA)
Author(s) -
O. V. Korkushko,
Valentina P. Chizhova,
Valeri Shatilo,
I. A. Antoniuk-Shcheglova,
Світлана Наскалова
Publication year - 2014
Publication title -
problemi endokrinnoï patologìï
Language(s) - English
Resource type - Journals
eISSN - 2518-1432
pISSN - 2227-4782
DOI - 10.21856/j-pep.2014.3.14
Subject(s) - medicine , endocrinology , insulin , impaired glucose tolerance , carbohydrate metabolism , insulin sensitivity , diabetes mellitus , insulin resistance , glucose homeostasis , dipeptidyl peptidase , homeostasis , islet , chemistry , enzyme , biochemistry
In order to study the eect of Saksagliptin on the indicators of the functional activity of thepancreas islets and indicators of glucose-insulin homeostasis in elderly patients with impaired glucosetolerance examined 69 people aged 60 years and older. It was carried out a standard glucose tolerancetest, determined the content of glucose and insulin, calculation of insulin resistance index, the indexof insulin sensitivity, functional activity β -cells of the pancreas, the area under curve of glucose, itwas determined insulin and C-peptide. From the total group in the result of screening were selected12 people with impaired glucose tolerance, which for the correction of violations during four weeksof the treatment by Saksagliptin 5 mg per day. Usage of Saksagliptin led to normalization of glucosetolerance in 9 out of 12 people (75 %), that indicating of the normalizing eect of DPP-IV inhibitorsin patients with glucose metabolism violation. Also it was indicated decrease of the insulin resistanceindex and increase of insulin sensitivity index (Matsuda index). It was concluded that the use ofSaksagliptin is a perspective for the correction of pre-diabetic disorders of glucose metabolism in theelderly.