Open AccessTHE EFFECT OF ARTERIAL HYPERTENSION AND GLUCOSE HOMEOSTASIS VIOLATIONS ON CARDIOMYOPATHY SEVERITY IN PATIENTS WITH ACROMEGALY
Author(s) -
Myroslava Mykytyuk
Publication year - 2013
Publication title -
problemi endokrinnoï patologìï
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 2
eISSN - 2518-1432
pISSN - 2227-4782
DOI - 10.21856/j-pep.2013.3.03
Subject(s) - medicine , cardiology , ejection fraction , diastole , ventricle , interventricular septum , blood pressure , left ventricular hypertrophy , acromegaly , endocrinology , heart failure , hormone , growth hormone
It was study 121 patients with acromegaly (75 women and 46 men) aged 18–75 years old.Changes of glucose homeostasis were presented violations by glucose tolerance (n = 9) and diabetesmellitus (n = 39). Hypertension was found in 74 patients. In patients with acromegaly without arterialhypertension the age, the thickness of the back wall of the left ventricle during diastole, the thicknessof the interventricular septum, the index of left ventricular mass (LVMI) and isovolumetric relaxationtime were significantly lower than in patients with hypertension, the ratio of the maximum velocityof early diastolic filling of the left ventricle and a top speed of left ventricular filling during atrialsystole (E/A) and ejection fraction (EF) were significantly higher. The results of multiple regressionanalysis showed that increased levels of growth hormone in the blood and systolic blood pressureare predictors of increased of LVMI. Elevated levels of diastolic blood pressure and the presence ofviolations of glucose homeostasis are predictors of reduction in ejection fraction (EF). Older patient’sage and increased levels of insulin-like growth factor-1 are predictors of increase in the ratio of E/A. Inpatients with arterial hypertension and normal glucose tolerance rate of left ventricular hypertrophywas significantly higher than in patients with normal glucose tolerance without hypertension, withoutsystolic (SLVD) and diastolic (DLVD) left ventricular dysfunction. In patients with hypertension anddiabetes frequency of the left ventricular hypertrophy, SLVD and DLVD was the highest.