Features of Changes in the Structural and Functional State of the Myocardium in Patients with Acute Myocardial Infarction Depending on Body Mass Index Considering FABP4 and CTRP3 Levels

. Adipokines such as fatty acid-binding protein 4 (FABP4) and C1qtumor necrosis factor-related protein 3 (CTRP3) can affect the structural and functionalstate of the myocardium in patients with acute myocardial infarction and obesity. The objective of the research was to determine the relationship between FABP4, CTRP3 andechocardiographic parameters of the left ventricular myocardium in patients with acutemyocardial infarction depending on body mass index. Materials and Methods. Theobservational cross-sectional study examined 189 patients with acute myocardialinfarction depending on body mass index, who were divided into the following groups:Group 1 included 60 patients with acute myocardial infarction and normal body massindex; Group 2 comprised 68 patients with acute myocardial infarction and excess bodyweight; Group 3 included 61 patients with acute myocardial infarction and obesity. Results. In Group 1, the statistical significance correlations were found: between FABP4and end-diastolic dimension (EDD; r = -0.458), end-systolic dimension (ESD; r = -0.460),end-diastolic volume (EDV; r = -0.452), left ventricular myocardial mass (LVMM; r =-0.411), LVMM/body surface area index (LVMMI2; r = -0.419); between CTRP3 and EDV (r =0.425), EDD (r = 0.469), left ventricular relative posterior wall thickness (LVRPWT; r =-0.469). In Group 2, there were found the statistical significance relationshipsbetween: FABP4 and EDD (r = 0.461), ESD (r = 0.467), EDV (r = 0.449), end-systolicvolume (ESV; r = 0.485), LVMM (r = 0.487), LVMMI1 (r = 0.406); between CTRP3 and EDD (r= -0.440), EDV (r = -0.413), LVMM (r = -0.430), LVMM/height2.7 index (LVMMI1; r =-0.483). In Group 3, the statistical significance correlations were found between: FABP4and EDV (r = 0.481), ESD (r = 0.411), ESV (r = 0.490), LVMMI1 (r = 0.403); between CTRP3and EDV (r = -0.326), ESD (r = -0.367), ESV (r = -0.453), LVMMI1 (r = -0.415). Conclusions. In patients with acute myocardial infarction and overweight/obesity,echocardiographic parameters had a significant low positive correlation with FABP4 and alow negative correlation with CTRP3. On the contrary, in patients with acute myocardialinfarction and normal body mass index, echocardiographic parameters had a significantlow negative correlation with FABP4 and a low positive correlation with CTRP3.