Open AccessRestorative Effects of Capsaicin Encapsulated Chitosan Nanoparticles on Chemically-Induced Hormone Receptor-Positive Mammary Carcinoma in Sprague-Dawley Rats
Author(s) -
Kalaiyarasi Dhamodharan
Publication year - 2022
Publication title -
bioscience biotechnology research communications
Language(s) - English
Resource type - Journals
eISSN - 2321-4007
pISSN - 0974-6455
DOI - 10.21786/bbrc/15.1.39
Subject(s) - hormone , population , mast cell , receptor , endocrinology , dmba , medicine , capsaicin , chemistry , pharmacology , cancer , immunology , carcinogenesis , environmental health
The clinical use of capsaicin has been confined due to its low-grade solubility and frail bioavailability. So, we examined the impact of capsaicin encapsulated chitosan nanoparticles (CAP@CS-NP) on chemically induced hormone receptor-positive mammary carcinoma. The mammary tumor was induced by a single dose of 7,12-Dimethylbenz(a)anthracene (DMBA) 25mg/kg b.wt. injected subcutaneously near the mammary gland. After 7 weeks, CAP@CS-NP 4mg/kg b.wt. was administered orally to tumor-bearing rats. Furthermore, sex hormones levels, ER and PR expression, mast cell population, and molecular docking studies were carried out. Tumor-bearing rats flashed significantly hoisted levels of sex hormones, mast cell population, ER, and PR expression. Administration of CAP@CS-NP 4mg/kg b.wt. restored the levels of sex hormones, mast cell population, ER, and PR expression to near-normal levels. Additionally, molecular docking revealed good binding affinity and best glide scores. These findings suggest that nano encapsulation of CAP@CS-NP 4mg/kg b.wt. administration can regulate hormonal expression to treat hormone receptor-positive mammary carcinoma