Open AccessAlterations in Various Biochemical Parameters Among Covid-19 Patients: An Observational Retrospective Analysis
Author(s) -
Arul Senghor Kadalangudi Aravaanan
Publication year - 2021
Publication title -
bioscience biotechnology research communications
Language(s) - English
Resource type - Journals
eISSN - 2321-4007
pISSN - 0974-6455
DOI - 10.21786/bbrc/14.4.42
Subject(s) - ferritin , creatinine , medicine , bilirubin , gastroenterology , albumin , covid-19 , respiratory distress , cytokine storm , c reactive protein , immunology , disease , physiology , inflammation , infectious disease (medical specialty) , surgery
Novel coronavirus causing the pandemic infectious disease termed as COVID-19 is characterized by respiratory illness which may lead on to acute respiratory distress syndrome. Ferritin is a key mediator of immune dysregulation leading on to cytokine storm. Alterations in various biochemical parameters have been widely reported in COVID-19. Early identification of effective biomarkers to assess the severity of this disease is essential. Our study was aimed to evaluate the variations in the routinely analysed biochemical parameters and their association with ferritin levels among COVID patients. The study participants consisted of 270 members among which 149 were COVID positive and 121 were negative. Analysis of the routine biochemical parameters as well as ferritin level were carried out. Among the 149 positive cases, 84 (56.4%) were mild positive with ferritin levels 500ng/ml. We reported significant increase in serum ferritin levels in severe positive samples (1449.84 ± 249.47) compared to mild positive samples (230.04 ± 17.41). We observed increased levels of total bilirubin in 12.7%, direct bilirubin in 16.8%, indirect bilirubin in 8.7%, AST in 65.8%, ALT in 44.3%, ALP in 9.4%, GGT in 51.7%, urea in 18.4%, creatinine in 14.3%, BUN in 18.4% and decreased levels of total protein and albumin in 23.5% positive patients compared to negative patients. Ferritin and its associated biochemical parameters act as predictors of COVID severity. These biochemical alterations suggest the significance of early risk assessment and monitoring of COVID patients.