Open AccessEfek Kefir Terhadap Kadar Superokdidase Dismutase, Malondialdehyde Pada Mencit Balb/C Diinduksi Streptococcus Agalactiae
Author(s) -
Mustika Dewi,
AUTHOR_ID,
Mega Ulfah,
AUTHOR_ID
Publication year - 2021
Publication title -
journal of issues in midwifery/journal of issues in midwifery
Language(s) - English
Resource type - Journals
eISSN - 2723-7230
pISSN - 2549-6581
DOI - 10.21776/ub.joim.2021.005.03.1
Subject(s) - streptococcus agalactiae , malondialdehyde , superoxide dismutase , streptococcus , microbiology and biotechnology , biology , immunology , bacteria , oxidative stress , endocrinology , genetics
Streptococcus agalactiae are pathogenic bacteria which cause vaginal infection. Vaginal and cervical infections in pregnant women can reduce elasticity of the membranes that cause premature rupture of membranes. This can also impact to neonatal morbidity and mortality in first week of birth. Kefir is known as a probiotic that can act as an immunomodulator. The role of kefir is believed to improve the immune system. The role of kefir in preventing infection is still rarely studied, especially as an immunomodulator and in reducing the number of pathogenic bacteria.This study aimed to evaluate superoxide dismutase (SOD) level, Malondialdehyde (MDA) level, and the population of the colonization Streptococcus agalactiae in BALB-C mice fed kefir. This study was true experimental with post test only control group design. Sample was BALB-C mice induced by Streptococcus agalactiae. SOD and MDA level was examined by enzyme-linked immunosorbent assay (ELISA) and Streptococcus agalactiae identification by colony count. The results of the one-way ANOVA analysis showed there was no significant differences between all groups for SOD levels (P 0.393). In the level of MDA there was also no difference between all groups (P 0.204). Whereas in the number of Streptococcus agalactiae colonies there was a significant difference (P 0.000) with the smallest number of colonies found at dose of 0.5 ml / day. Conclusion: kefir as a probiotic drink did not affect to the SOD and MDA level of BALB/ C mice induced by Streptococcus agalactiae, but kefir affected to number of Streptococcus agalactiae colonies. Further research needs to show the relation of kefir as probiotics with proinflammatory and other anti-inflammatory parameters such as interleukin and immunological vaginal mucosa.