Open AccessPotensi Ekstrak Etanol Ubi Jalar Ungu sebagai Inhibitor Angiotensin Converting Enzyme pada Tikus Hipertensi
Author(s) -
Irma Sarita Rahmawati,
Soetjipto Soetjipto,
Annis Catur Adi,
Aulanni’am Aulanni’am,
Annisa Rizky Maulidiana
Publication year - 2021
Publication title -
ijhn (indonesian journal of human nutrition)/ijhn : indonesian journal of human nutrition
Language(s) - English
Resource type - Journals
eISSN - 2442-6636
pISSN - 2355-3987
DOI - 10.21776/ub.ijhn.2021.008.01.9
Subject(s) - chlorogenic acid , chemistry , ethanol , renin–angiotensin system , angiotensin converting enzyme , food science , anthocyanin , ethyl acetate , oxidative stress , pharmacology , blood pressure , biochemistry , endocrinology , medicine
There is an increasing amount of evidence that oxidative stress related to hypertension can damage the function of diverse structures such as the aorta and kidney. It is a well-established fact that chlorogenic acid and anthocyanin found in purple sweet potato generates bioactive compound with antihypertensive and anti-ACE activities in RAA system. The present study sought to investigate anti-ACE activities in RAA system of extract ethanol of purple sweet potato (EP) in deoxycorticosterone acetate (DOCA–salt)–induced hypertensive rats ( Rattus norvegicus ). The rats were orally administrated a 95% ethanol extract of purple sweet potato (var. ayamurasaki) (EP) in a daily dose of 200 and 400 mg/kg body weight also chlorogenic acid (CA) of 700 mg/kg bw for 4 weeks. Activity of renin, ACE, and Ang II concentration were assessed. Inhibiting activity of renin, ACE, and decreasing Ang II concentration after treatment was observed in the DOCA-salt hypertensive rats compared to normotensive group rats; (P<0.05). This is the first report that demonstrates the lowering of blood pressure and anti-ACE in RAA-system effects of an ethanol extract of purple sweet potato, containing chlorogenic acid, in a DOCA–salt model of hypertension.