Open AccessDIURETIC RESISTANCE IN ADVANCED HEART FAILURE: A Literature Review
Author(s) -
Anita Surya Santoso,
Mohammad Saifur Rohman,
Indra Prasetya,
Budi Satrijo
Publication year - 2021
Publication title -
heart science journal
Language(s) - English
Resource type - Journals
eISSN - 2721-9984
pISSN - 2721-9976
DOI - 10.21776/ub.hsj.2021.002.01.02
Subject(s) - decompensation , diuretic , heart failure , medicine , cardiac decompensation , cardiology , intensive care medicine , population , signs and symptoms , furosemide , environmental health
Advanced heart failure (HF) is used to characterized patients in HF with severe symptoms, recurrent decompensation and severe cardiac dysfunction. The prevalencekof HFkis approximatelyg1-2% of thecadult population inhdeveloped countries and it will be rising more than 10%pamongapeoplec>70ayears of age, whereas estimated theoprevalence ofcpatients with advanced HF is about 1% until 10%cof thekoverallkHFopopulation. Most ofkthe HF hospitalizationssare due to signs and symptoms of fluidcoverload.Recurrent congestionccould worsen patientssoutcomes.Loopdiureticssare recommended for thectreatmentcofkcongestionqinprHF patient. cHowever,cdiureticvresistanceeispavcommon problem issueiinpacuteqdecompensationtofcadvancedochronicrheartwfailureq(ACHF) patients and established prognostic factor. Some early reports estimated the prevalence of diuretic resistance about 20%-30% in HF population. In this review, we will be discuss how to diagnose the advancedvheartufailurepand the underlying mechanism of diuretic resistancebin HF patients. We also describe pharmacologicalvand non-pharmacologicalstrategies to overcome this issue.