Open AccessImmunity Modulators, Repurposed Drugs and Candidate Vaccines for COVID-19: A Review
Author(s) -
R. P. N. Nair,
Ravindra Singh Rao,
P. J. John,
Poonam Khandelwal
Publication year - 2021
Publication title -
coronaviruses
Language(s) - English
Resource type - Journals
eISSN - 2666-7975
pISSN - 2666-7967
DOI - 10.2174/2666796702999210112203139
Subject(s) - repurposing , pandemic , covid-19 , medicine , intensive care medicine , coronavirus , death toll , immunity , disease , virology , immunology , biology , infectious disease (medical specialty) , immune system , environmental health , ecology , pathology
COVID-19, a pandemic has led the whole globe through unprecedented times and unpredictabilitythat has adversely affected the humanity as a whole. Although the severe acute respiratorysyndrome was reported in the year 2002-2004 of zoonotic origin caused by SARS-CoV-1 strain.Now recently, in December 2019, SARS-CoV-2 virus has emerged and swiftly spread to the wholeworld, taking a heavy toll on life. Studies are being conducted worldwide to find antiviral drugs actingspecifically on the virus and to develop the vaccine for the disease. The present review articlesummarizes the currently undergoing clinical trials of Indian Ayurvedic herbs and their role in promotingimmunity. It also includes studies focused on repurposing the existing drugs and finding alternativetreatment methods that can be opted for potential treatment/management of COVID-19.Last but not the least, this paper provides a background on the development of preventive vaccinesand the various bioinformatic tools utilized in order to help accelerate the research on coronavirus.The manuscript gives a brief outline of all the possible strategies and therapeutics underway in Indiaand at the global level to fight against the microscopic adversary and lead to an affordable andspeedy remedy for COVID-19.