Open AccessGreen Synthesis of Substituted Dihydropyrimidin-2(1H)-one by Using Zinc Chloride /Acetic Acid Catalytic System
Author(s) -
Bapu R. Thorat,
Ankita Gurav,
Bharat Dalvi,
Ashwini Sawant,
Vikas Lokhande,
Suraj N. Mali
Publication year - 2021
Publication title -
current chinese chemistry
Language(s) - English
Resource type - Journals
eISSN - 2666-0016
pISSN - 2666-0008
DOI - 10.2174/2665997201999200512110147
Subject(s) - chemistry , catalysis , zinc , acetic acid , ferric , cyclohexanone , biginelli reaction , yield (engineering) , organic chemistry , cobalt , inorganic chemistry , nuclear chemistry , materials science , metallurgy
Background: Biginelli reaction is the most well-known and widely studied, multicomponentreaction used for the direct synthesis of many biologically active 3,4-dihydropyrimidin-2(1H)-ones and their derivatives by reacting a β-keto ester/1,3-dicarbonyl compound, an aldehyde,and urea. It is catalyzed by different Bronsted and Lewis acids. Methods: The catalytic effect of different metal chlorides, such as sodium, potassium, magnesium,stannous, ferric, manganese, cupric, nickel, cobalt, and zinc, in absence and presence of acetic acidwere studied. Results: The zinc, ferric, cupric, and cobalt chlorides were found to be more effective catalysts forBiginelli reaction at room temperature. The yield of the reaction increased with temperature for allcatalytic systems. Acetophenone, cyclohexanone, acetyl acetone, and different β-ketoesters formedtetrahedropyrimidine in moderate to good yield, by using zinc chloride catalyst at roomtemperature in acetic acid. The efficiency of the catalyst was studied by treating differentsubstituted aldehydes with 1,3-dicarbonyl compounds and urea at room temperature. Conclusion: The zinc chloride in acetic acid found to be an effective greener catalyst system forBiginelli reaction.