Open AccessGankyrin Oncoprotein: Structure, Function, and Involvement in Cancer
Author(s) -
Junan Li,
Yi Guo
Publication year - 2010
Publication title -
current chemical biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.155
H-Index - 22
eISSN - 2212-7968
pISSN - 1872-3136
DOI - 10.2174/2212796811004010013
Subject(s) - cancer research , regulator , cancer , suppressor , biology , cyclin dependent kinase , chemical biology , computational biology , cell cycle , genetics , gene
Gankyrin, a newly defined oncoprotein also known as PSMD10 and P28, functions as a dual-negative regulator of the two most prominent tumor suppressor pathways, the CDK/pRb and HDM2/P53 pathways. Its aberrant expression has been prevalently found in human hepatocellular carcinomas (HCC) and esophagus squamous cell carcinomas (ESCC), indicative of the potential of gankyrin as a rational diagnostic and therapeutic target in cancers. Here, we review the unique structural features and functional diversity of gankyrin, and discuss its implication in cancer diagnostics and therapeutics from the perspective of chemical biology.