Open AccessNovel (N4) Macrocyclic Metal Complexes: Synthesis, Characterization, Spectral Studies and Anticancer Activity
Author(s) -
Hanaa A. ElBoraey,
Ohyla A. ELGammal
Publication year - 2018
Publication title -
open chemistry journal
Language(s) - English
Resource type - Journals
ISSN - 1874-8422
DOI - 10.2174/1874842201805010051
Subject(s) - octahedral molecular geometry , molar conductivity , chemistry , methylene , ligand (biochemistry) , square pyramidal molecular geometry , metal , elemental analysis , thermal analysis , octahedron , crystallography , stereochemistry , inorganic chemistry , medicinal chemistry , crystal structure , thermal , organic chemistry , biochemistry , physics , receptor , meteorology
A new series of mononuclear Fe(II), Co(II), Ni(II), Cu(II) and Pd(II) complexes correspond to tetradentate macrocyclic nitrogen ligand i.e. naphthyl-3,4:10,11-dibenzo,7-methylene,8-methyl,6-phenyl-1,5,9,13-tetraazacyclohexadecane-5,8-diene-2,12-dione metal(II) complexes, have been synthesized by the template condensation reaction. Methods: The complexes have been characterized by elemental analysis, spectral (IR, UV–Vis, and ESR, molar conductivity, and magnetic as well as thermal analysis measurements. Results: On the basis of above studies, an octahedral geometry has been proposed for all complexes except Cu(II) nitrate complex that adopt square pyramidal geometry, and square planar geometry for Pd(II) chloride complex, respectively. Conclusion: The thermal behavior and the kinetic parameters of degradation were determined using Coats-Redfern and Horowitz-Metzger methods. Moreover, the in vitro antitumor activity of the some synthesized complexes against human breast and human hepatocarcinoma cell lines (MCF-7) and (HePG2), respectively has been studied.