Open AccessOxidant and Antioxidant Effects of Gentisic Acid in a 177Lu-Labelled Methionine-Containing Minigastrin Analogue
Author(s) -
Victoria Trindade,
Henia Balter
Publication year - 2020
Publication title -
current radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.586
H-Index - 25
eISSN - 1874-4729
pISSN - 1874-4710
DOI - 10.2174/1874471012666190916112904
Subject(s) - gentisic acid , chemistry , methionine , peptide , residue (chemistry) , antioxidant , amino acid , oxidizing agent , radical , labelling , biochemistry , organic chemistry , salicylic acid
The radiolabelling of receptor-binding peptides for therapy is a challenge since the peptide itself is exposed (during labelling, storage and transport) to radiation-induced damage, directly or indirectly, in aqueous solution. Hence, the use of radiostabilizers seems to be mandatory, especially in peptide molecules that contain radiation-sensitive amino acids.