Open AccessNuezhenide Exerts Anti-Inflammatory Activity through the NF-κB Pathway
Author(s) -
Qinqin Wang,
Shan Han,
Xinxing Li,
Renyikun Yuan,
Youqiong Zhuo,
Xinxin Chen,
Chenwei Zhang,
Yangling Chen,
Hongwei Gao,
Lichun Zhao,
Shilin Yang
Publication year - 2020
Publication title -
current molecular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.717
H-Index - 39
eISSN - 1874-4702
pISSN - 1874-4672
DOI - 10.2174/1874467213666200611141337
Subject(s) - reactive oxygen species , flow cytometry , western blot , microbiology and biotechnology , inflammation , apoptosis , nf κb , proinflammatory cytokine , chemistry , biology , signal transduction , biochemistry , immunology , gene
Nuezhenide (NZD), an iridoid glycoside isolated from Ilex pubescens Hook. & Arn. var. kwangsiensis Hand.-Mazz., used as a traditional Chinese medicine for clearing away heat and toxic materials, displays a variety of biological activities such as anti-tumor, antioxidant, and other life-protecting activities. However, a few studies involving anti-inflammatory activity and the mechanism of NZD have also been reported. In the present study, the anti-inflammatory and antioxidative effects of NZD are illustrated.