Open AccessThe Influence of Lactobacillus Acidophilus on MUC1, GAL-3, IL-1β and IL-17 Gene Expression in BALB/c Mice Stomach
Author(s) -
Fanny Rahardja,
Dwi Prasetyo,
M. Nurhalim Shahib,
Susy Tjahjani
Publication year - 2021
Publication title -
the open microbiology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.502
H-Index - 27
ISSN - 1874-2858
DOI - 10.2174/1874285802115010067
Subject(s) - lactobacillus acidophilus , stomach , saline , balb/c , biology , medicine , immunology , bacteria , endocrinology , probiotic , immune system , genetics
Background and Objective: Lactobacillus acidophilus has been widely used for the management of gastrointestinal carcinoma owing to its immunomodulation effect; however, the role of L. acidophilus and its specific mechanism of action in the stomach is not fully comprehended. The present study evaluated the expression profile of MUC-1, GAL-3 , IL -1β , and IL-17 in the L. acidophilus treated mice stomach. Methods: The study was conducted utilizing three groups of mice, 6 mice for each group, administered with different doses of L. acidophilus and a control group treated with normal saline. The results were analyzed with the Mann-Whitney Test. Results: The results demonstrated that L. acidophilus elevated IL-1β insignificantly and inhibited the expression of IL-17. The MUC-1 expression is influenced by L. acidophilus and inversely proportional to GAL-3 expression. Conclusion: Lactobacillus acidophilus plays a prominent role against inflammatory responses and has a potential in the treatment of gastrointestinal cancer.