Open AccessHuman Amniotic Fluid for the Treatment of Hospitalized, Symptomatic, and Laboratory-verified SARS-CoV-2 Patients
Author(s) -
Mojgan Barati,
Fakher Rahim
Publication year - 2021
Publication title -
the open biology journal
Language(s) - English
Resource type - Journals
ISSN - 1874-1967
DOI - 10.2174/1874196702109010036
Subject(s) - amniotic fluid , covid-19 , medicine , pandemic , transmission (telecommunications) , intensive care medicine , fibrosis , cystic fibrosis , disease , pregnancy , virology , pathology , biology , infectious disease (medical specialty) , fetus , genetics , outbreak , electrical engineering , engineering
New reports offer evidence that under different circumstances, intrauterine mother-infant transmission of SARS-CoV-2 occurs. In contrast, early observations in the COVID-19 pandemic recommended that vertical transmission from women infected with SARS-CoV-2 can be challenging and no virus is detected in human amniotic fluid (HAF). The present study aimed to propose the idea that HAF can be used as a potential therapy for hospitalized, symptomatic, and laboratory-verified SARS-CoV-2 patients by mitigating COVID-19 related inflammation and decreasing its fibrosis. Considering that COVID-19 can cause a severe pulmonary fibrotic response in some patients, HAF by decreasing fibrosis may be considered as an alternative and novel therapy against COVID-19. Lastly, given the inexpensive, easy to access, and safe nature of HAF, integrating this therapy may decrease the COVID-19 attributed death and burden to the health system, especially in countries with limited access to vaccines where HAF is widely available.