Open AccessProtein Aggregation in the Cell Nucleus: Structure, Function and Topology
Author(s) -
Anna von Mikecz
Publication year - 2009
Publication title -
the open biology journal
Language(s) - English
Resource type - Journals
ISSN - 1874-1967
DOI - 10.2174/1874196700902010193
Subject(s) - chromatin , ribonucleoprotein , nucleus , heterogeneous nuclear ribonucleoprotein , nucleic acid , chemistry , cell nucleus , dna , microbiology and biotechnology , ubiquitin , computational biology , heterogeneous ribonucleoprotein particle , function (biology) , rna , nuclear protein , biophysics , topology (electrical circuits) , biology , biochemistry , transcription factor , gene , mathematics , combinatorics
The nucleus represents a cellular control unit that regulates all events concerning the storage and processing ofDNA and RNA. It is organized by highly crowded, dynamic assemblies of proteins and nucleic acids in molecularmachines, ribonucleoprotein complexes, clusters of ongoing nuclear processes, nuclear bodies, and chromatin. Thisreview discusses the occurrence of nuclear protein aggregation with special emphasis on the functional architecture of thenucleus, and quality control by the ubiquitin-proteasome system.