Open AccessOptimization of Extraction Process for Polysaccharide in Salvia Miltiorrhiza Bunge Using Response Surface Methodology
Author(s) -
Yanhua Wang,
Fuhua Wu,
Guo Zhaohan,
Mingxing Peng,
Yanan Zhang,
Pang Zhen Ling,
DU Min-hua,
Caiying Zhang,
Zian Liang
Publication year - 2014
Publication title -
the open biomedical engineering journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.15
H-Index - 22
ISSN - 1874-1207
DOI - 10.2174/1874120701408010153
Subject(s) - salvia miltiorrhiza , response surface methodology , extraction (chemistry) , polysaccharide , comminution , computer science , chromatography , machine learning , materials science , chemistry , medicine , metallurgy , biochemistry , alternative medicine , pathology , traditional chinese medicine
This study was aimed to optimize the extraction process for Salvia miltiorrhiza Bunge polysaccharide using response surface methodology The results showed that four operating parameters including microwave power, microwave time and the particle size had notable effects on the polysaccharide extraction of Salvia miltiorrhiza Bunge. The effects could be ranked in decreasing order of importance as follows:. Microwave power > microwave time > the comminution degree. The optimal extraction parameters were determined as 573.83W of Microwave power and 8.4min of microwave time and 67.51mesh of the comminution degree, resulting in the yield of Salvia miltiorrhiza Bunge polysaccharide of 101.161mg / g. The established regression model describing polysaccharide extraction from as a function of the three extraction parameters was highly significant (R 2 = 0.9953). The predicted and experimental results were found to be in good agreement. Thus, the model can be applicable for the prediction of polysaccharide extraction from Salvia miltiorrhiza Bunge.