Open AccessSynthesis of Medicinally Important Indole Derivatives: A Review
Author(s) -
Praveen Kumar Sharma,
Tanzeela Qadir,
Andleeb Amin,
Sarkar Deeptanu
Publication year - 2021
Publication title -
the open medicinal chemistry journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.294
H-Index - 18
ISSN - 1874-1045
DOI - 10.2174/1874104502015010001
Subject(s) - indole test , solvent , microwave irradiation , combinatorial chemistry , ionic liquid , catalysis , chemistry , organic chemistry , nanotechnology , materials science
Indoles constitute a widely occurring functional group in nature and are present in an extensive number of bioactive natural products and medicinally important compounds. As a result, exponential increases in the development of novel methods for the formation of indole core along with site-specific indoles have been established. Conventional methods for the synthesis of indoles are getting replaced with green methods involving ionic liquids, water as a solvent, solid acid catalyst, microwave irradiation and the use of nanoparticles under solvent-free conditions. In addition, there are immense applications of the substituted indoles in diverse fields.