Open AccessCytotoxic, DNA Cleavage and Pharmacokinetic Parameter Study of Substituted Novel Furan C-2 Quinoline Coupled 1, 2, 4-Triazole and Its Analogs
Author(s) -
R. Anantacharya,
N. D. Satyanarayan,
Bhuvanesh Sukhlal Kalal,
Vidya Pai
Publication year - 2018
Publication title -
the open medicinal chemistry journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.294
H-Index - 18
ISSN - 1874-1045
DOI - 10.2174/1874104501812010060
Subject(s) - quinoline , chemistry , cytotoxic t cell , dna , furan , mtt assay , cleavage (geology) , stereochemistry , biochemistry , biology , cell growth , organic chemistry , in vitro , paleontology , fracture (geology)
Furan, quinoline and triazoles are known for their wide spectrum biologically active molecules. A series of novel furan C-2 quinoline and 1, 2, 4-triazole (FQT) coupled hybrids were designed and synthesized to evaluate for their DNA cleavage and cytotoxic studies.