Open AccessTransport of Bupropion and its Metabolites by the Model CHO and HEK293 Cell Lines
Author(s) -
Lyrialle W. Han,
Chunying Gao,
Yuchen Zhang,
Joanne Wang,
Qingcheng Mao
Publication year - 2019
Publication title -
drug metabolism letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.302
H-Index - 27
eISSN - 1874-0758
pISSN - 1872-3128
DOI - 10.2174/1872312813666181129101507
Subject(s) - chemistry , multidrug resistance associated protein 2 , transporter , pharmacology , hek 293 cells , active metabolite , efflux , bioavailability , chinese hamster ovary cell , metabolite , biochemistry , atp binding cassette transporter , biology , receptor , gene
Bupropion (BUP) is widely used as an antidepressant and smoking cessation aid. There are three major pharmacologically active metabolites of BUP, Erythrohydrobupropion (EB), Hydroxybupropion (OHB) and Threohydrobupropion (TB). At present, the mechanisms underlying the overall disposition and systemic clearance of BUP and its metabolites have not been well understood, and the role of transporters has not been studied.