Open AccessFuture Perspective of Diabetic Animal Models
Author(s) -
Shashank K. Pandey,
Magdalena Chottová Dvoráková
Publication year - 2020
Publication title -
endocrine, metabolic and immune disorders. drug targets
Language(s) - English
Resource type - Journals
eISSN - 2212-3873
pISSN - 1871-5303
DOI - 10.2174/1871530319666190626143832
Subject(s) - animal model , nod , clinical trial , animal testing , disease , animal studies , diabetes mellitus , medicine , biomedicine , consistency (knowledge bases) , bioinformatics , biology , computer science , endocrinology , genetics , artificial intelligence
The need of today's research is to develop successful and reliable diabetic animal models for understanding the disease susceptibility and pathogenesis. Enormous success of animal models had already been acclaimed for identifying key genetic and environmental factors like Idd loci and effects of microorganisms including the gut microbiota. Furthermore, animal models had also helped in identifying many therapeutic targets and strategies for immune-intervention. In spite of a quite success, we have acknowledged that many of the discovered immunotherapies are working on animals and did not have a significant impact on human. Number of animal models were developed in the past to accelerate drug discovery pipeline. However, due to poor initial screening and assessment on inequivalent animal models, the percentage of drug candidates who succeeded during clinical trials was very low. Therefore, it is essential to bridge this gap between pre-clinical research and clinical trial by validating the existing animal models for consistency.