Open AccessMetabolic Association between Leptin and the Corticotropin Releasing Hormone
Author(s) -
Sofia Gioldasi,
Alexia Karvela,
Andrea Paola Rojas Gil,
Maria Rodi,
Anne-Lise de Lastic,
Ιάσων Θωμάς,
Bessie E. Spiliotis,
Αthanasia Mouzaki
Publication year - 2019
Publication title -
endocrine, metabolic and immune disorders. drug targets
Language(s) - English
Resource type - Journals
eISSN - 2212-3873
pISSN - 1871-5303
DOI - 10.2174/1871530319666190206165626
Subject(s) - leptin , medicine , endocrinology , adipose tissue , corticotropin releasing hormone , adipokine , hormone , hypothalamus , appetite , biology , obesity
In healthy individuals, leptin is produced from adipose tissue and is secreted into the circulation to communicate energy balance status to the brain and control fat metabolism. Corticotropin- Releasing Hormone (CRH) is synthesized in the hypothalamus and regulates stress responses. Among the many adipokines and hormones that control fat metabolism, leptin and CRH both curb appetite and inhibit food intake. Despite numerous reports on leptin and CRH properties and function, little has been actually shown about their association in the adipose tissue environment.