Open AccessToxicity Evaluation of the Subacute Diazinon in Aged Male Rats: Hematological Aspects
Author(s) -
Saeed Samarghandian,
Tahereh Farkhondeh,
Shahnaz Yousefizadeh
Publication year - 2020
Publication title -
cardiovasular and hematological disorders. drug targets
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 40
eISSN - 2212-4063
pISSN - 1871-529X
DOI - 10.2174/1871529x20666200305103007
Subject(s) - mean corpuscular volume , mean corpuscular hemoglobin concentration , mean corpuscular hemoglobin , hematocrit , hemoglobin , toxicity , diazinon , medicine , physiology , red blood cell , endocrinology , biology , pesticide , agronomy
Background & Objective:: Age-dependent Organophosphates (OPs) toxicity is a controversialtopic. The present study was designed to investigate the effect of the sub-acute exposure todiazinon (DZN), one of the main OPs insecticides, on the hematological alterations in adult andaged male rats. Methods: For the aim of this approach, the adult and aged rats were administered with DZN (15 mg/kg,orally) for 4 weeks. Then, the blood samples were collected from the retro-orbital sinus for measuringred blood cell (RBC), hemoglobin (Hb), hematocrit (Hct), platelets (PLT), MCV (mean corpuscularvolume), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin (MCHC). Results: The obtained results indicated that DZN significantly decreased RBCs (4.93 ± 0.41), Htc(28.12 ± 1.21), Hb (10.31 ± 0.36), MCHC (30.51 ± 2.04), MCV (62.86 ± 2.58), and PLT (265.6 ±34.81) values in the adult and aged rats versus the age-matched control rats. Moreover, RBC, Hb,and Htc levels decreased significantly in the aged rats versus adult rats. However, no significantdifferences were observed between MCHC, MCV, and PLT levels in adult and aged rats. Moreover,the MCH concentration did not change in any group. Additionally, DZN did not deteriorate the hematologicalalterations in the aged rats versus adult rats. Conclusion: The present study showed that the toxicity of DZN is not associated with age. However,more studies should be conducted to confirm this finding.