Open AccessHypolipidemic and Antioxidant Activities of Corrigiola telephiifolia in Diabetic Rats
Author(s) -
Morad Hebi,
Mohamed Eddouks
Publication year - 2019
Publication title -
cardiovascular and hematological agents in medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 39
eISSN - 1875-6182
pISSN - 1871-5257
DOI - 10.2174/1871525717666190227231834
Subject(s) - antioxidant , streptozotocin , triglyceride , chemistry , diabetes mellitus , endocrinology , medicine , cholesterol , oral administration , lipid profile , aqueous extract , traditional medicine , biochemistry
Objective: The evaluation of the hypolipidemic and antioxidant activities of the aerialparts aqueous extract of Corrigiola telephiifolia (APAE of C. telephiifolia) in normal and streptozotocin(STZ)-induced diabetic rats. Methods: The effects of oral administration of APAE of C. telephiifolia (5 mg/kg) on the lipid profileas well as the in vitro antioxidant activity of this aqueous extract have been determined. Results: APAE of C. telephiifolia (5 mg/kg) reduced significantly (p<0.001) the plasma total cholesterollevels in diabetic rats. In contrast, no significant increase in plasma triglyceride levels in normaland in STZ-induced diabetic rats was observed. On the other hand, APAE of C. telephiifolia showedan antioxidant activity. Conclusion: The APAE of C. telephiifolia exhibits an antioxidant, cholesterol and body weightloweringactivities in diabetic rats.