Open AccessSynthesis and Biological Activity of a Bis-steroid-methanocyclobutanaphthalene- dione Derivative against Ischemia/Reperfusion Injury via Calcium Channel Activation
Author(s) -
Lauro FigueroaValverde,
Francisco Díaz-Cedillo,
RosasNexticapa Marcela,
MateuArmand Virginia,
GarcimareroEspino E. Alejandra,
LópezRamos Maria,
Hau-Heredia Lenin,
BorgesBallote Yaritza,
Cabrera-Tuz Jhair
Publication year - 2020
Publication title -
anti-inflammatory and anti-allergy agents in medicinal chemistry
Language(s) - English
Resource type - Journals
eISSN - 1875-614X
pISSN - 1871-5230
DOI - 10.2174/1871523018666191003152854
Subject(s) - nifedipine , ischemia , nisoldipine , reperfusion injury , steroid , derivative (finance) , chemistry , pharmacology , levosimendan , calcium , ventricular pressure , medicine , cardiology , blood pressure , inotrope , hormone , financial economics , economics
There is some experimental data on the effect exerted by some steroid derivatives against ischemia/reperfusion injury; however, the molecular mechanism is very confusing, perhaps this phenomenon could be due to the protocols used and/or differences in the chemical structure of each one of the steroid derivatives.