Open AccessProgranulin Regulates Inflammation and Tumor
Author(s) -
Chunxiao Liu,
Jiayi Li,
Wenjing Shi,
Liujia Zhang,
Shuang Liu,
Yingcong Lian,
Shuai Liang,
Hongyan Wang
Publication year - 2020
Publication title -
anti-inflammatory and anti-allergy agents in medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.296
H-Index - 23
eISSN - 1875-614X
pISSN - 1871-5230
DOI - 10.2174/1871523018666190724124214
Subject(s) - carcinogenesis , inflammation , cancer , cancer research , neurodegeneration , medicine , cell growth , immunology , disease , biology , pathology , genetics
Progranulin (PGRN) mediates cell cycle progression and cell motility as a pleiotropic growth factor and acts as a universal regulator of cell growth, migration and transformation, cell cycle, wound healing, tumorigenesis, and cytotoxic drug resistance as a secreted glycoprotein. PGRN overexpression can induce the secretion of many inflammatory cytokines, such as IL-8, -6,-10, TNF-α. At the same time, this protein can promote tumor proliferation and the occurrence and development of many related diseases such as gastric cancer, breast cancer, cervical cancer, colorectal cancer, renal injury, neurodegeneration, neuroinflammatory, human atherosclerotic plaque, hepatocarcinoma, acute kidney injury, amyotrophic lateral sclerosis, Alzheimer's disease and Parkinson's disease. In short, PGRN plays a very critical role in injury repair and tumorigenesis, it provides a new direction for succeeding research and serves as a target for clinical diagnosis and treatment, thus warranting further investigation. Here, we discuss the potential therapeutic utility and the effect of PGRN on the relationship between inflammation and cancer.