Open AccessMitigation of Radiation-induced Pneumonitis and Lung Fibrosis using Alpha-lipoic Acid and Resveratrol
Author(s) -
Rasool Azmoonfar,
Peyman Amini,
Rasoul Yahyapour,
Abolhasan Rezaeyan,
Alireza Tavassoli,
Elahe Motevaseli,
Ehsan Khodamoradi,
Dheyauldeen Shabeeb,
Ahmed Eleojo Musa,
Masoud Najafi
Publication year - 2020
Publication title -
anti-inflammatory and anti-allergy agents in medicinal chemistry
Language(s) - English
Resource type - Journals
eISSN - 1875-614X
pISSN - 1871-5230
DOI - 10.2174/1871523018666190319144020
Subject(s) - resveratrol , fibrosis , pulmonary fibrosis , medicine , pneumonitis , lung , pathology , pharmacology
Lung is a radiosensitive organ. Studies have shown that exposure of the lung to acute and high doses of radiation following inhalation of radioactive agents or an accidental radiological event may lead to pneumonitis and fibrosis, which are associated with a risk of death. So far, some agents have been studied for mitigation of pneumonitis and fibrosis following exposure of murine lung tissues to ionizing radiation. In this study, we aimed to detect the possible mitigatory effect of alpha-lipoic acid, resveratrol and their combination on mice pneumonitis and fibrosis markers following irradiation.