Open AccessOptimization of Microemulgel for Tizanidine Hydrochloride
Author(s) -
Swati Jagdale,
Sujata Brahmane,
Anuruddha R. Chabukswar
Publication year - 2020
Publication title -
anti-inflammatory and anti-allergy agents in medicinal chemistry
Language(s) - English
Resource type - Journals
eISSN - 1875-614X
pISSN - 1871-5230
DOI - 10.2174/1871523018666190308123100
Subject(s) - microemulsion , tizanidine , pulmonary surfactant , chromatography , bioavailability , chemistry , viscosity , zeta potential , isopropyl myristate , materials science , pharmacology , spasticity , medicine , composite material , anesthesia , nanotechnology , biochemistry , nanoparticle
Tizanidine hydrochloride acts centrally as a muscle relaxant. It is used for the treatment of painful muscle spasm, spasticity associated with multiple sclerosis or spinal cord injury and treatment of muscle spasticity in spinal cord disease. Tizanidine hydrochloride belongs to BCS class II. It has low oral bioavailability and short halflife. Incorporating this drug in microemulgel is an excellent way to overcome problems associated with the drug.