Open AccessSynthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer Agents
Author(s) -
Nikhil Reddy Madadi,
Narsimha Reddy Penthala,
Amit Ketkar,
Robert L. Eoff,
Vicenta Trujullo-Alonso,
Mónica L. Guzmán,
Peter A. Crooks
Publication year - 2018
Publication title -
anti-cancer agents in medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.508
H-Index - 96
eISSN - 1875-5992
pISSN - 1871-5206
DOI - 10.2174/1871521409666170412115703
Subject(s) - chemistry , naphthalene , moiety , bromide , sodium methoxide , combretastatin , molecule , methanol , combinatorial chemistry , organic chemistry , medicinal chemistry , stereochemistry , microtubule , tubulin , biology , microbiology and biotechnology
Naphthalene is a good structural replacement for the isovanillin moiety (i.e. the 3- hydroxy-4-methoxyphenyl unit) in the combretastatin A-4 molecule, a natural product structurally related to resveratrol, which consistently led to the generation of highly cytotoxic naphthalene analogues when combined with a 3,4,5-trimethoxyphenyl or related aromatic system. Also, the naphthalene ring system is present in many current drug molecules that are utilized for anti-tumor, anti-arrhythmia and antioxidant therapy.