Open AccessChemical Constituents and Antitumor Mechanisms of Artemisia
Author(s) -
Yasin Kamarya,
Xia Li,
Jinyao Li
Publication year - 2022
Publication title -
anti-cancer agents in medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.508
H-Index - 96
eISSN - 1875-5992
pISSN - 1871-5206
DOI - 10.2174/1871520621666210708125230
Subject(s) - artemisia , cancer , apoptosis , angiogenesis , cell cycle checkpoint , medicine , pharmacology , chemistry , cancer research , traditional medicine , cell cycle , biochemistry
Background: At present, chemotherapy is still the main treatment for cancer, but its side effects andmultidrug resistance limit the therapeutic efficacy. Natural products are the important sources for the development ofantitumor drugs with higher efficiency and lower toxicity. Artemisia contains a variety of antitumor constituents, whichcan induce tumor cell apoptosis and cell cycle arrest, inhibit tumor angiogenesis, and accelerate iron ion-mediatedoxidative damage. Objective: This paper provides a focused, up-to-date, and comprehensive overview of the antitumor active constituentsand mechanisms of Artemisia. Method: The relevant references on Artemisia and its bioactive components were obtained from scientific databases,including PubMed, Web of Science, and Science Direct. Results: We have summarized the current progress about on the bioactive components and mechanisms of Artemisia.The application prospect of active components of Artemisia in cancer prevention and treatment has also been discussed. Conclusion: This review may provide new ideas for the follow-up treatment of cancer and contribute to the developmentof safe and effective antitumor drugs.