Open AccessFAK and Nanog Cross Talk with p53 in Cancer Stem Cells
Author(s) -
Vita M. Golubovskaya
Publication year - 2013
Publication title -
anti-cancer agents in medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.508
H-Index - 96
eISSN - 1875-5992
pISSN - 1871-5206
DOI - 10.2174/1871520611313040006
Subject(s) - homeobox protein nanog , focal adhesion , stem cell , cancer stem cell , microbiology and biotechnology , cancer research , biology , signal transduction , transcription factor , cancer cell , induced pluripotent stem cell , embryonic stem cell , cancer , genetics , gene
This review is focused on the role of Focal Adhesion Kinase (FAK) signaling in cancer stem cells. The recent data demonstrate the important role of FAK in cancer stem cell proliferation, differentiation, motility, and invasion. We showed recently that the transcription factor Nanog binds the FAK promoter and up-regulates FAK expression, and that FAK binds Nanog and phosphorylates it. This review discusses the interaction of FAK, Nanog, Oct-3/4, and Sox-2 signaling pathways that are critical for the regulation of cancer stem cells. The cross-linked signaling of FAK with p53 and Nanog signaling in cancer stem cell and function and targeted therapeutics approaches are discussed.