Open AccessIdentification of Novel Cyclin A2 Binding Site and Nanomolar Inhibitors of Cyclin A2-CDK2 Complex
Author(s) -
Stephanie S. Kim,
Michele Joana Alves,
Patrick Gygli,
José Otero,
Steffen Lindert
Publication year - 2021
Publication title -
current computer-aided drug design
Language(s) - English
Resource type - Journals
eISSN - 1875-6697
pISSN - 1573-4099
DOI - 10.2174/1573409916666191231113055
Subject(s) - cyclin a , cyclin dependent kinase 2 , cyclin dependent kinase , cyclin a2 , cyclin e , cyclin d , chemistry , cyclin dependent kinase complex , biology , microbiology and biotechnology , biochemistry , cell cycle , cell
Given the diverse roles of cyclin A2 both in cell cycle regulation and in DNA damage response, identifying small molecule regulators of cyclin A2 activity carries significant potential to regulate diverse cellular processes in both ageing/neurodegeneration and in cancer.