Open AccessDesign and Synthesis of New Substituted Pyrazolopyridines with Potent Antiproliferative Activity
Author(s) -
Vassiliki Giannouli,
Nikolaos Lougiakis,
Ioannis K. Kostakis,
Nicole Pouli,
Panagiotis Marakos,
AlexiosLéandros Skaltsounis,
David Horne,
Sangkil Nam,
Katerina Gioti,
Ρωξάνη Τέντα
Publication year - 2020
Publication title -
medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.308
H-Index - 44
eISSN - 1875-6638
pISSN - 1573-4064
DOI - 10.2174/1573406415666190222130225
Subject(s) - pharmacology , computational biology , chemistry , medicine , biology
Purine isosteres are often endowed with interesting pharmacological properties, due to their involvement in cellular processes replacing the natural purines. Among these compounds, pyrazolopyridines are under active investigation for potential anticancer properties.