Open AccessTrigger, Signaling Mechanism and End Effector of Cardioprotective Effect of Remote Postconditioning of Heart
Author(s) -
Л Н Маслов,
S. Yu. Tsibulnikov,
Е. С. Прокудина,
С. В. Попов,
Alla A. Boshchenko,
Nirmal Singh,
Yi Zhang,
Peter R. Oeltgen
Publication year - 2019
Publication title -
current cardiology reviews
Language(s) - English
Resource type - Journals
eISSN - 1875-6557
pISSN - 1573-403X
DOI - 10.2174/1573403x15666190226095820
Subject(s) - medicine , effector , cardioprotection , protein kinase b , microbiology and biotechnology , nitric oxide , signal transduction , adenosine , kinase , immunology , ischemia , biology
The hypothetical trigger of remote postconditioning (RPost) of the heart is the highmolecular weight hydrophobic peptide(s). Nitric oxide and adenosine serve as intermediaries between the peptide and intracellular structures. The role of the autonomic nervous system in RPost requires further study. In signaling mechanism RPost, kinases are involved: protein kinase C, PI3, Akt, JAK. The hypothetical end effector of RPost is aldehyde dehydrogenase-2, the transcription factors STAT, Nrf2, and also the BKCa channel.