Open AccessTRPV1 Activation Prevents Renal Ischemia-Reperfusion Injury-Induced Increase in Salt Sensitivity by Suppressing Renal Sympathetic Nerve Activity
Author(s) -
Shuang-Quan Yu,
Shuangtao Ma,
Donna H. Wang
Publication year - 2020
Publication title -
current hypertension reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.486
H-Index - 20
eISSN - 1875-6506
pISSN - 1573-4021
DOI - 10.2174/1573402115666191112122339
Subject(s) - capsaicin , trpv1 , medicine , endocrinology , kidney , agonist , renal function , ischemia , renal injury , renal ischemia , receptor , transient receptor potential channel , anesthesia , reperfusion injury
Salt sensitivity is increased following renal Ischemia-Reperfusion (I/R) injury. We tested the hypothesis that high salt intake induced increase in Renal Sympathetic Nerve Activity (RSNA) after renal I/R can be prevented by activation of Transient Receptor Potential Vanilloid 1 (TRPV1).