Open AccessSynthesis of Novel Fluorine Compounds Substituted-4-thiazolidinones Derived from Rhodanine Drug as Highly Bioactive Probes
Author(s) -
Mohammad. S. T. Makki,
Reda M. AbdelRahman,
Nawaa Ali H. Alshammari
Publication year - 2019
Publication title -
current organic synthesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.292
H-Index - 46
eISSN - 1875-6271
pISSN - 1570-1794
DOI - 10.2174/1570179416666190312150046
Subject(s) - rhodanine , chemistry , alkyl , fluorine , enzyme , combinatorial chemistry , stereochemistry , organic chemistry
It is known that rhodanine drug has various biocidal activities. The aim of this work was to improve the structure of rhodanine drug via alkylation at N, S, and O- centers in addition to the introduction of fluorine atoms. The new fluorinated modified rhodanines 2-16 were evaluated as enzymatic probes for cellobiase activity produced by fungi and as CDK2 inhibitors of tumor cells.