Open AccessMicrobial Translocation and Immune Activation in HIV-1 Infected Pregnant Women
Author(s) -
Charles D. Mitchell,
S. Dominguez,
Margaret Roach,
Valérie George,
Stefano Rinaldi,
Margaret A. Fischl,
JoNell Potter,
Brittany Tyson,
Savita Pahwa
Publication year - 2018
Publication title -
current hiv research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.561
H-Index - 52
eISSN - 1873-4251
pISSN - 1570-162X
DOI - 10.2174/1570162x16666180731145011
Subject(s) - pregnancy , cd38 , medicine , human immunodeficiency virus (hiv) , immune system , viral load , prospective cohort study , antiretroviral therapy , immunology , postpartum period , obstetrics , physiology , biology , genetics , stem cell , cd34
Immune Activation (IA) has been previously documented in both pregnant (PG) and non-PG HIV-1 infected (HIV+) women as well as in HIV- uninfected PG women; the latter as a result of the fetal allograft. To determine whether the combined effects of HIV and pregnancy result in increased IA and whether IA is associated with Microbial Translocation (MT), we performed a prospective, longitudinal, controlled study during pregnancy and the postpartum (PP) period.