Open AccessFlavonoids, the Family of Plant-Derived Antioxidants Making Inroads into Novel Therapeutic Design Against Ionizing Radiation-Induced Oxidative Stress in Parkinson’s Disease
Author(s) -
Tapan Behl,
Gagandeep Kaur,
Aayush Sehgal,
Gökhan Zengin,
Sukhbir Singh,
Amirhossein Ahmadi,
Simona Bungău
Publication year - 2022
Publication title -
current neuropharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.955
H-Index - 73
eISSN - 1875-6190
pISSN - 1570-159X
DOI - 10.2174/1570159x19666210524152817
Subject(s) - oxidative stress , reactive oxygen species , parkinson's disease , neuroprotection , ionizing radiation , microglia , dopaminergic , medicine , disease , neuroscience , microbiology and biotechnology , biology , pharmacology , cancer research , bioinformatics , immunology , inflammation , dopamine , pathology , irradiation , physics , nuclear physics
Ionizing radiation from telluric sources is unceasingly an unprotected pitfall to humans. Thus, the foremost contributors to human exposure are global and medical radiations. Various evidences assembled during preceding years reveal the pertinent role of ionizing radiation- induced oxidative stress in the progression of neurodegenerative insults, such as Parkinson's disease, which have been contributing to increased proliferation and generation of reactive oxygen species.