Open AccessThe Role of ASIC1a in Epilepsy: A Potential Therapeutic Target
Author(s) -
Yuanda Cheng,
Wuqiong Zhang,
Yue Li,
Ting Jiang,
Buhajar Mamat,
Yunhai Zhang,
Famin Wang,
Hongmei Meng
Publication year - 2021
Publication title -
current neuropharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.955
H-Index - 73
eISSN - 1875-6190
pISSN - 1570-159X
DOI - 10.2174/1570159x19666210402102232
Subject(s) - epileptogenesis , epilepsy , neuroscience , mechanism (biology) , medicine , ion channel , bioinformatics , biology , receptor , philosophy , epistemology
Epilepsy represents one of the most common brain diseases among humans. Tissue acidosis is a common phenomenon in epileptogenic foci. Moreover, its role in epileptogenesis remains unclear. Acid-sensing ion channel-1a (ASIC1a) represents a potential way to assess new therapies. ASIC1a, mainly expressed in the mammalian brain, is a type of protein-gated cation channel. It has been shown to play an important role in the pathological mechanism of various diseases, including stroke, epilepsy, and multiple sclerosis.