Open Access5-HT3 Receptor Antagonism: A Potential Therapeutic Approach for the Treatment of Depression and other Disorders
Author(s) -
Shvetank Bhatt,
Thangaraj Devadoss,
S. Manjula,
Jayaraman Rajangam
Publication year - 2021
Publication title -
current neuropharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.955
H-Index - 73
eISSN - 1875-6190
pISSN - 1570-159X
DOI - 10.2174/1570159x18666201015155816
Subject(s) - serotonergic , serotonin , monoamine neurotransmitter , psychology , major depressive disorder , neuroscience , anxiety , medicine , receptor , psychiatry , amygdala
Depression or Major depressive disorder (MDD) is a prolonged condition of sadness. MDD is the most common mental disorder that affects more than 264 million people worldwide. According to the monoamine hypothesis, serotonin (5-hydroxy tryptamine, 5-HT), dopamine (DA) and norepinephrine (NE) are the major neurotransmitters (NTs) involved in depression.