Open AccessTargeting Ionotropic Glutamate Receptors in the Treatment of Epilepsy
Author(s) -
Roberta Celli,
Francesco Fornai
Publication year - 2021
Publication title -
current neuropharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.955
H-Index - 73
eISSN - 1875-6190
pISSN - 1570-159X
DOI - 10.2174/1570159x18666200831154658
Subject(s) - ionotropic effect , kainate receptor , perampanel , metabotropic glutamate receptor , pharmacology , epilepsy , glutamate receptor , neuroscience , long term depression , metabotropic receptor , medicine , receptor , ampa receptor , biology
A dysfunction in glutamate neurotransmission is critical for seizure. Glutamate is the major excitatory drive in the cerebral cortex, where seizures occur. Glutamate acts via (i) ionotropic (iGlu) receptors, which are ligand-gated ion channels mediating fast excitatory synaptic transmission; and (ii) G proteins coupled metabotropic (mGlu) receptors.