Open AccessRole of Grina/Nmdara1 in the Central Nervous System Diseases
Author(s) -
Kai Chen,
Liu Nan Yang,
Chuan Lai,
Dan Liŭ,
LingQiang Zhu
Publication year - 2020
Publication title -
current neuropharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.955
H-Index - 73
eISSN - 1875-6190
pISSN - 1570-159X
DOI - 10.2174/1570159x18666200303104235
Subject(s) - neuroscience , schizophrenia (object oriented programming) , glutamate receptor , epilepsy , nmda receptor , ionotropic effect , depression (economics) , central nervous system , medicine , stroke (engine) , disease , receptor , psychiatry , biology , macroeconomics , economics , mechanical engineering , engineering
Glutamate receptor, ionotropic, N-methyl-D-aspartate associated protein 1 (GRINA) is a member of the NMDA receptors (NMDARs) and is involved in several neurological diseases, which governs the key processes of neuronal cell death or the release of neurotransmitters. Upregulation of GRINA has been reported in multiple diseases in human beings, such as major depressive disorder (MDD) and schizophrenia (SCZ), with which the underlying mechanisms remain elusive. In this review, we provide a general overview of the expression and physiological function of GRINA in the central nervous system (CNS) diseases, including stroke, depression ,epilepsy, SCZ, and Alzheimer's disease (AD).