Open AccessModeling Neuronal Diseases in Zebrafish in the Era of CRISPR
Author(s) -
Ángeles Edith Espino-Saldaña,
Roberto Rodríguez-Ortiz,
Elizabeth PereidaJaramillo,
Ataúlfo Martı́nez-Torres
Publication year - 2020
Publication title -
current neuropharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.955
H-Index - 73
eISSN - 1875-6190
pISSN - 1570-159X
DOI - 10.2174/1570159x17666191001145550
Subject(s) - crispr , zebrafish , neuroscience , danio , genome editing , function (biology) , computational biology , model organism , disease , cas9 , brain development , biology , computer science , medicine , genetics , pathology , gene
Danio rerio is a powerful experimental model for studies in genetics and development. Recently, CRISPR technology has been applied in this species to mimic various human diseases, including those affecting the nervous system. Zebrafish offer multiple experimental advantages: external embryogenesis, rapid development, transparent embryos, short life cycle, and basic neurobiological processes shared with humans. This animal model, together with the CRISPR system, emerging imaging technologies, and novel behavioral approaches, lay the basis for a prominent future in neuropathology and will undoubtedly accelerate our understanding of brain function and its disorders.