Open AccessSelf-Assembled Tocopherol-Albumin Nanoparticles with Full Biocompatibility for Chemo-photothermal Therapy against Breast Cancer
Author(s) -
Honglie Shen,
Qianqian Gao,
Tingting Liu,
Haoran Wang,
Ran Zhang,
Jie Zhou,
Sihui Ding,
Yunbo Yang,
Zhenhua Sun
Publication year - 2022
Publication title -
current drug delivery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.449
H-Index - 62
eISSN - 1875-5704
pISSN - 1567-2018
DOI - 10.2174/1567201819666211229120611
Subject(s) - photothermal therapy , biocompatibility , doxorubicin , in vivo , indocyanine green , chemistry , photothermal effect , nanotechnology , materials science , chemotherapy , medicine , pathology , surgery , microbiology and biotechnology , organic chemistry , biology
Background: The combination of photothermal therapy (PTT) and chemotherapy hasproven to be a promising strategy for cancer treatment. Various nanomaterials have shown great potentialin combination therapy, including gold, graphene oxide, iron oxide, and other nanoparticles.However, their undefinable toxicity in vivo greatly slowed down their development for clinical applications. Objective: The present work aimed to develop a multifunctional nanoparticle for chemo-photothermaltherapy composed of acknowledged biocompatible materials. Methods: A novel biocompatible nanoparticle (HIT-NPs) was self-assembled through the intrinsicinteraction between D-α-tocopherol Succinate (TOS), human serum albumin (HSA) and indocyaninegreen (ICG). Doxorubicin (DOX) was then loaded due to the ion pairing between DOX andTOS. The feasibility of combined chemo-photothermal therapy induced by DOX-loaded HIT-NPswas carefully evaluated. Results: In vitro, HIT-NPs showed no cytotoxicity on human normal liver cells (HL-7702 cells)but obvious killing effects on murine breast cancer cells (4T1 cells). The combined chemo-photothermaltherapeutic effect on 4T1 cells was successfully obtained. DOX-loaded HIT-NPs couldeffectively accumulate in 4T1 subcutaneous tumors after intravenous injection, and the tumor temperaturerapidly increased under laser exposure, indicating the feasibility of PTT in vivo. Conclusion: The self-assembled HIT-NPs could provide a promising platform for combined chemo-photothermal cancer therapy with full biocompatibility.