Open AccessFanconi Anemia DNA Repair Pathway as a New Mechanism to Exploit Cancer Drug Resistance
Author(s) -
Kajal Ghosal,
Christian Agatemor,
Richard I. Han,
Amy T. Ku,
Sabu Thomas,
Sudit Mukherjee
Publication year - 2020
Publication title -
mini-reviews in medicinal chemistry/mini-reviews in medical chemistry
Language(s) - English
Resource type - Journals
eISSN - 1875-5607
pISSN - 1389-5575
DOI - 10.2174/1389557520666200103114556
Subject(s) - fanconi anemia , cancer , drug resistance , dna repair , mechanism (biology) , medicine , drug , cancer research , biology , bioinformatics , pharmacology , dna , genetics , philosophy , epistemology
Chemotherapy employs anti-cancer drugs to stop the growth of cancerous cells, but one common obstacle to the success is the development of chemoresistance, which leads to failure of the previously effective anti-cancer drugs. Resistance arises from different mechanistic pathways, and in this critical review, we focus on the Fanconi Anemia (FA) pathway in chemoresistance. This pathway has yet to be intensively researched by mainstream cancer researchers. This review aims to inspire a new thrust toward the contribution of the FA pathway to drug resistance in cancer. We believe an indepth understanding of this pathway will open new frontiers to effectively treat drug-resistant cancer.